| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802472 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2013 | 11 Pages |
Abstract
⺠MEK overexpression induces C-Raf hyper-phosphorylation and activation. ⺠Co-expression of wildtype C-Raf and MEK constitutively activates ERK MAPK. ⺠MEK-induced C-Raf activation is Ras independent. ⺠MEK-induced C-Raf activation requires C-Raf-MEK interaction. ⺠MEK is a novel, Ras-independent C-Raf activator.
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Authors
Deborah T. Leicht, Vitaly Balan, Jun Zhu, Alexander Kaplun, Agnieszka Bronisz, Ajay Rana, Guri Tzivion,