| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802478 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2013 | 11 Pages |
Abstract
⺠In mammals, MAVS is involved in the antiviral innate immunity. ⺠We examined the MAVS-regulatory mechanism in live cells using BRET system. ⺠Activated MAVS conformation is a highly ordered oligomer. ⺠MAVS inhibitors differentially affect the MAVS homotypic oligomerization. ⺠We provide structural insight into mitochondrial-mediated antiviral signaling.
Keywords
NF-κBproline rich regionHR1IRF-3RLRMAVSRlucRIG-IPRRNLRX1BiFCHEKMfnsIFN-βbioluminescence resonance energy transferAntiviral innate immunityinterferon βBRETbimolecular fluorescence complementationrenilla luciferaseVenusmitochondrial antiviral signalingInterferon regulatory factor 3nuclear factor κBcaspase activation and recruitment domainmitofusinsMitochondriaSignal transductionHepatitis C virusHCVretinoic acid-inducible gene ICARDhuman embryonic kidneyRIG-I-like receptor
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Authors
Osamu Sasaki, Takuma Yoshizumi, Misa Kuboyama, Takeshi Ishihara, Emiko Suzuki, Shun-ichiro Kawabata, Takumi Koshiba,