| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802480 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2013 | 13 Pages |
Abstract
⺠The study highlights the higher efficacy of nano-gefitinib over gefitinib alone. ⺠GNPs caused higher cell death in A431 and A549 cells as compared to gefitinib. ⺠GNPs also prove to be effective in gefitinib resistant cells (H1975). ⺠Histone H3 acetylation played a pivotal role in higher potency of nano-gefitinib. ⺠Role of histone acetylation was confirmed by inhibiting HATs(p300/CBP) by garcinol.
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Authors
Jasmine Kaur, Kulbhushan Tikoo,