Article ID Journal Published Year Pages File Type
10802487 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2013 11 Pages PDF
Abstract
► NF-κB super-repressor overexpression sensitizes HeLa cells to TNFα-induced apoptosis. ► The specific knockdown of Bcl-xL sensitizes cells to TNFα-triggered apoptosis. ► The NF-κB pathway activated by TNFα is still functional in Bcl-xL-downregulated cells. ► Bcl-xL silencing does not increase TNFα-induced apoptosis in NF-κB-repressed cells. ► TNFα-induced NF-κB-mediated cell survival relies on the anti-apoptotic role of Bcl-xL.
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