| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802491 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2013 | 10 Pages |
Abstract
⺠Microtubule (MT) dynamic instability was followed using the PlusTipTracker software. ⺠Nek7 kinase downregulation or absence reduces MT growth and shrinkage speeds. ⺠Nek7 downregulation reduces the relative time spent in shrinkage and MT dynamicity. ⺠Ectopic overexpression of Nek7 yields inverse dynamic characteristics. ⺠Our results provide a mechanistic explanation for Nek7 impact on mitosis and cancer.
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Authors
Sivan Cohen, Adva Aizer, Yaron Shav-Tal, Amiel Yanai, Benny Motro,