Article ID Journal Published Year Pages File Type
10802492 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2013 11 Pages PDF
Abstract
► MCP-1 was highly expressed in OA synovial fibroblasts as compared with normal SFs. ► CTGF mediates the monocyte migration in OASFs by up-regulation of MCP-1 production. ► CTGF acts through the αvβ5 integrin, FAK, MEK, and ERK to induce MCP-1 activation. ► NF-κB and AP-1 are two key transcription factors of CTGF-induced MCP-1 activation.
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CTGF induces monocyte chemoattractant protein-1 expression to enhance monocyte migration in human synovial fibroblasts
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