| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802502 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2013 | 10 Pages |
Abstract
⺠RNA helicase Ddx5 physically interacts with the RBP-J/NICD complex. ⺠RNA helicase Ddx5 is found at Notch target genes in vivo. ⺠RNA helicase Ddx5 acts as a co-activator in Notch signaling. ⺠The long non-coding RNA SRA associates with Ddx5 and NICD in T-cells and is a positive regulator of Notch signaling. ⺠Occupancy of p300 and histone acetylation is lost upon SRA knockdown and overexpression at Notch target genes.
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Authors
Claudia Jung, Gerhard Mittler, Franz Oswald, Tilman Borggrefe,