| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802529 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2012 | 6 Pages |
Abstract
⺠Small molecule Hsp90 inhibitors promote client protein degradation via the actions of molecular chaperones. ⺠Hsp90 can promote degradation as well as protect against degradation of misfolded proteins. ⺠Several ubiquitin ligases in the degradation of Hsp90 client proteins including CHIP, Ubr1 and Cul5. ⺠Inhibition of Hsp90 can protect against neurodegeneration.
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Authors
Maria A. Theodoraki, Avrom J. Caplan,