| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802532 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2012 | 9 Pages |
Abstract
⺠Viruses are intracellular pathogens responsible for a vast number of human diseases. ⺠The molecular chaperone Hsp90 is nearly universally required for viral protein replication. ⺠The unique characteristics of viral replication cause viruses to be hypersensitive to pharmacological inhibitors of Hsp90. ⺠The ubiquitous requirement for Hsp90 provides a novel therapeutic avenue for development of broad-spectrum antiviral drugs.
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Authors
Ron Geller, Shuhei Taguwa, Judith Frydman,