| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802538 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2012 | 12 Pages |
Abstract
âºNormal cells secrete Hsp90 only under a stress, whereas tumor cells secrete Hsp90 always. âºSecreted Hsp90α is an unconventional pro-motility factor, independent of ATPase. âºSecreted Hsp90α, but not conventional growth factors, works against TGFβ inhibition. ⺠Topical application of Hsp90α protein promotes acute and chronic wound healing. ⺠Drugs that selectively target F-5 region of Hsp90 may be more effective and less toxic than those targeting the ATPase.
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Authors
Wei Li, Divya Sahu, Fred Tsen,