| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802548 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2012 | 13 Pages |
Abstract
⺠We provide an overview of the current classification of AAA+ proteins. ⺠The characteristic features of the AAA+ nucleotide binding pocket are presented. ⺠We assemble biochemical data summarising the effects of site directed mutations in the nucleotide binding pocket. ⺠We assess the structural conservation of AAA+ domains and their nucleotide binding pockets. ⺠PDB structures of oligomeric AAA+ proteins are examined regarding protomer interactions at the nucleotide binding pocket.
Keywords
Pyrococcus furiosusAAA+ ATPasesLarge T-antigenMethanocaldococcus jannaschiiLTAGPyrobaculum aerophilumThermus thermophilusBacillus subtilisAquifex aeolicusRattus norvegicusAeropyrum pernixThermoplasma acidophilumFunctional analysisEscherichia coliStructural analysisThermotoga maritimaSalmonella TyphimuriumSaccharomyces cerevisiaeMus musculusHomo sapiensSimian virus
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Authors
Petra Wendler, Susanne Ciniawsky, Malte Kock, Sebastian Kube,