| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802556 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2012 | 16 Pages |
Abstract
⺠AAA-ATPases, generators of mechanical force, are key players in protein degradation throughout evolution. ⺠Archaeal PAN homo-hexameric ring provides insights into structure and function of eukaryotic hetero-hexameric Rpt ring. ⺠Exciting findings show the role of the C-termini of proteasomal AAA-ATPases in opening the proteolytic chamber 'gate'. ⺠Novel discoveries on assembly pathways lead to revised spatial arrangement of eukaryotic hetero-hexameric Rpt ring. ⺠Functional studies emphasize the unique contribution of each individual Rpt subunit to various cellular processes.
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Authors
Shoshana Bar-Nun, Michael H. Glickman,