| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802577 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2012 | 6 Pages |
Abstract
⺠Spastin is a microtubule severing ATPase and mutations in the gene encoding spastin cause axonal degeneration. ⺠Nâterminal spastin domains serve to recruit it to cellular sites of action. ⺠A hydrophobic domain localizes spastin to the endoplasmic reticulum. ⺠The MIT domain recruits spastin to endosomes and the cytokinetic midbody. ⺠Spastin regulates microtubules in relation to sites of membrane modelling.
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Authors
Jennifer H. Lumb, James W. Connell, Rachel Allison, Evan Reid,