| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802581 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2012 | 9 Pages |
Abstract
⺠SHIP1 is a crucial negative regulator of B cell antigen receptor signal transduction. ⺠The SH2-domain of SHIP1 binds to the phospho-ITAM of Ig-α in vitro and in vivo. ⺠The SH2-domain of SHIP1 binds to the phospho-Y1020 in its C-terminus. ⺠Thus, SHIP1 is able to dimerize and potentially form larger oligomers. ⺠This intermolecular interaction of SHIP1 competes against SHIP1/Ig-α interaction.
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Authors
Oindrilla Mukherjee, Lars Weingarten, Inken Padberg, Catrin Pracht, Rileen Sinha, Thomas Hochdörfer, Stephan Kuppig, Rolf Backofen, Michael Reth, Michael Huber,