Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10802584 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2012 | 9 Pages |
Abstract
⺠We determined IDE transcript levels in human brain and cell cultures over-expressing NICD, HES-1 or Hey-1 cDNAs. ⺠We detected extracellular Aβ accumulation in N2aSW cells after NICD or Hey-1 transfection. ⺠HES-1 and Hey-1 bind to the consensus domain located at position â 310/â 305 of human IDE promoter. ⺠Site-directed mutagenesis of the â 310/â 305 binding site reverts the inhibition of IDE transcription ⺠Notch signaling exerts an inhibitory effect on IDE transcription in vitro (N2aSW cells) and in vivo (Tg2576 mice).
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Authors
MarÃa C. Leal, Ezequiel I. Surace, MarÃa P. Holgado, Carina C. Ferrari, Rodolfo Tarelli, Fernando Pitossi, Thomas Wisniewski, Eduardo M. Castaño, Laura Morelli,