Acquisition of mitochondrial dysregulation and resistance to mitochondrial-mediated apoptosis after genotoxic insult in normal human fibroblasts: A possible model for early stage carcinogenesis

Article ID	Journal	Published Year	Pages	File Type
10802588	Biochimica et Biophysica Acta (BBA) - Molecular Cell Research	2012	9 Pages	PDF

Abstract

âº Normal cells made death-resistant after exposure to Cr(VI) âº Resistant cells retain Bcl-2 expression and show no caspase 3 cleavage after Cr(VI) âº Resistant cells do not undergo mitochondrial-mediated apoptosis after Cr(VI) exposure âº Resistant cells exhibit less basal mtDNA damage âº Mitochondrial dysregulation may be indicative of early stage carcinogenesis

Keywords

∆ψm TGA ND1 NADH dehydrogenase 1 Mitochondrial DNA hTERT ROS Smac/DIABLO Human telomerase mtDNA Mitochondria Mitochondrial membrane potential Genotoxin Cr(VI)Hexavalent chromium Chromium Reactive oxygen species

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

Preview

Acquisition of mitochondrial dysregulation and resistance to mitochondrial-mediated apoptosis after genotoxic insult in normal human fibroblasts: A possible model for early stage carcinogenesis

Authors

Kristen P. Nickens, Ying Han, Harini Shandilya, Ashley Larrimore, Gary F. Gerard, Eric Kaldjian, Steven R. Patierno, Susan Ceryak,