Stimulation of Ca2Â +-sensing receptor inhibits the basolateral 50-pS K channels in the thick ascending limb of rat kidney

► The patch-clamp experiments were performed in the thick ascending limb (TAL). ► Stimulation of Ca2 +-receptor by raising external Ca2 + inhibits basolateral K channels in the TAL. ► The basolateral K channel activity determines transepithelial voltage (Vte). ► Vte provides the driving force for transepithelial Ca2 + absorption in the TAL. ► Regulation of Ca2 + absorption in the TAL may be achieved by modulating basolateral K channels.