Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10802595 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2012 | 10 Pages |
Abstract
⺠Phagocyte NADPH oxidase (phox) is crucial to microbicidal activity of neutrophils. ⺠Modulation by peroxiredoxin 6 (Prdx6) presents a novel paradigm for phox. ⺠Prdx6 moves to plasma membrane and enhances activity in neutrophils and K562 line. ⺠Prdx6 retains phox complex in phox competent K562 cells. ⺠Prdx6 is critical for optimal phox activity.
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Authors
Daniel R. Ambruso, Michael A. Ellison, Gail W. Thurman, Thomas L. Leto,