| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802605 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2012 | 11 Pages |
Abstract
⺠Cholinergic stimulation induces anti-inflammatory response in skeletal muscle cells. ⺠Tristetraprolin is an essential player in the cholinergic anti-inflammatory pathway in muscles. ⺠Cholinergic signaling regulates the expression of mRNA processing factors and their apoptosis-related targets. ⺠Cholinergic imbalances in the neuromuscular junction alter polyA site selection in the anti-apoptotic Mcl-1 gene. ⺠Together, cholinergic signaling in muscle cells regulates inflammatory and apoptosis-related transcripts.
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Authors
Brian C. Geyer, Shani Ben Ari, Shahar Barbash, Jacqueline Kilbourne, Tsafrir S. Mor, Hermona Soreq,