| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802612 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2012 | 10 Pages |
Abstract
⺠HOCl exposure in the uM range causes to human macrophages to undergo a calcium dependent necrotic cell death. ⺠HOCl causes the Ca+ to enter the cytoplasm via plasma membrane L- and T- type Ca+ channels and RyR channels from the ER. ⺠Blocking of Ca+ channels or addition of calpain inhibitors prevents mitochondrial potential loss and lysosome failure. ⺠HOCl cause HMDM cell death through destabilization of cytosolic calcium control.
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Authors
Ya-ting Tina Yang, Matthew Whiteman, Steven P. Gieseg,