eIF4F complex disruption causes protein synthesis inhibition during hypoxia in nerve growth factor (NGF)-differentiated PC12 cells

Article ID	Journal	Published Year	Pages	File Type
10802613	Biochimica et Biophysica Acta (BBA) - Molecular Cell Research	2012	9 Pages	PDF

Abstract

âº Hypoxia induces protein synthesis inhibition in differentiated PC12 cells. âº Hypoxia-induced translation inhibition occurs primarily by eIF4F complex disruption. âº Translocation of eIF4E to the nucleus mediates eIF4F complex inhibition. âº Increased levels and dephosphorylation of 4E-BP1 mediate eIF4F complex disruption. âº Inhibition of mTOR by REDD1/HIF1 pathway produces 4E-BP1 dephosphorylation.

Keywords

AMPK eukaryotic initiation factor 4E-binding protein 1 mTOR Redd1 TSC eIF2 NGF 4E-BP1 eIF2α HIF AMP-activated protein kinase eIF Akt Translation initiation Eukaryotic Initiation Factor nerve growth factor Hypoxia Inducible Factor Translation inhibition mammalian target of rapamycin Hypoxia Tuberous sclerosis complex

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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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eIF4F complex disruption causes protein synthesis inhibition during hypoxia in nerve growth factor (NGF)-differentiated PC12 cells

Authors

Macarena Hernández-Jiménez, M. Irene Ayuso, M. Isabel Pérez-Morgado, Eva M. GarcÃa-Recio, Alberto Alcázar, M. Elena MartÃn, VÃctor M. González,