| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802618 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2012 | 7 Pages |
Abstract
⺠IGF-1 increases SREBP-2 activation acutely. ⺠IGF-1 activates SREBP-2 via PI3K, as determined by two specific PI3K inhibitors. ⺠Pharmacological and siRNA inhibition of Akt also decreases SREBP-2 activation. ⺠Specifically inducing activation of Akt with rapalog increases SREBP-2 activation. ⺠Active Akt increases both mature (active) SREBP-2, and its downstream gene targets.
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Authors
Winnie Luu, Laura J. Sharpe, Julian Stevenson, Andrew J. Brown,