Article ID Journal Published Year Pages File Type
10802619 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2012 11 Pages PDF
Abstract
► PAK4 nuclear export is mediated by CRM-1-dependent pathway. ► PAK4 interacts with and phosphorylates β-catenin on Ser675. ► PAK4 phosphorylation of β-catenin on Ser675 promotes its transcriptional activity. ► Nuclear import of PAK4 accompanies with the nuclear import of β-catenin. ► PAK4 associates with the TCF/LEF transcriptional complex.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Nucleo-cytoplasmic shuttling of PAK4 modulates β-catenin intracellular translocation and signaling
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