Article ID Journal Published Year Pages File Type
10802622 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2012 9 Pages PDF
Abstract
► We show that RNAi of human FDX1 compromises iron-sulfur cluster biogenesis. ► We also show that RNAi of human FDX2 compromises iron-sulfur cluster biogenesis. ► The two homologous human ferredoxins function in iron-sulfur cluster biogenesis. ► RNAi of the human FDX reductase (FDXR) compromises iron-sulfur cluster biogenesis. ► FDX-FDXR dysfunction disturbs mitochondrial and cytosolic iron homeostasis.
Keywords
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis
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