| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802625 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2012 | 9 Pages |
Abstract
⺠Both FcγRIIB receptor and Kv1.3 channel are expressed in malignant Daudi B cells. ⺠Compared to normal lymphocytes, Kv1.3 channel is highly expressed in Daudi cells. ⺠Kv1.3 channel in Daudi cells does not inactivate completely as normal lymphocytes. ⺠Rituximab inhibits Kv1.3 channel by promoting its inactivation via FcγRIIB receptor. ⺠Rituximab reduces membrane potential and induces apoptosis via FcγRIIB receptor.
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Authors
Li-Hua Wang, Ning Wang, Xiao-Yu Lu, Bing-Chen Liu, Murali K. Yanda, John Z. Song, Helena M. Dai, Yu-Liang Sun, Hui-Fang Bao, Douglas C. Eaton, He-Ping Ma,