Article ID Journal Published Year Pages File Type
10802629 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2012 10 Pages PDF
Abstract
► DJ-1/PARK7 mutations have been linked with a familial form of early onset PD. ► DJ-1 wild type and the missense mutants M26I, R98Q, A104T and D149A are stable proteins in the cell. ► DJ-1 L166P mutant is unstable because of its direct endoproteolytic degradation by the proteasome. ► Genetic evidence obtained in yeast shows the direct role of proteasome in degradation of DJ-1 L166P.
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