Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10802629 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2012 | 10 Pages |
Abstract
⺠DJ-1/PARK7 mutations have been linked with a familial form of early onset PD. ⺠DJ-1 wild type and the missense mutants M26I, R98Q, A104T and D149A are stable proteins in the cell. ⺠DJ-1 L166P mutant is unstable because of its direct endoproteolytic degradation by the proteasome. ⺠Genetic evidence obtained in yeast shows the direct role of proteasome in degradation of DJ-1 L166P.
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Authors
Beatriz Alvarez-Castelao, Carolina Muñoz, Isabel Sánchez, Marc Goethals, Joël Vandekerckhove, José G. Castaño,