Phosphatidylinositol 3-kinase and protein kinase D1 specifically cooperate to negatively regulate the insulin-like growth factor signaling pathway

Article ID	Journal	Published Year	Pages	File Type
10802633	Biochimica et Biophysica Acta (BBA) - Molecular Cell Research	2012	12 Pages	PDF

Abstract

âº PI 3-kinase and PKD1cooperate to inhibit the IGF-I pathway at the level of IRS-1. âº PKD1 is activated independently of PI 3-kinase. âº PKD1 interacts with IRS-1 in response to EGF and FGF. âº PI 3-kinase, but not PKD1, induces the ser-307 phosphorylation of IRS-1. âº IRS-1 Ser-307 phosphorylation is not sufficient per se to inhibit the IGF signaling.

Keywords

IGF FGF ERK IRS Protein kinase D1 Type 1 IGF receptor PKD1 PKC EGF IGF-IR PI 3-kinase insulin receptor substrate insulin receptor substrate 1 epidermal growth factor fibroblast growth factor Insulin-like growth factor Phosphatidylinositol 3-kinase Protein kinase C extracellular signal-regulated kinase insulin receptor Tyrosine kinase receptor