Functional interaction of protein kinase CK2 and activating transcription factor 4 (ATF4), a key player in the cellular stress response

Article ID	Journal	Published Year	Pages	File Type
10802643	Biochimica et Biophysica Acta (BBA) - Molecular Cell Research	2013	13 Pages	PDF

Abstract

âº ATF4 is a new binding partner of protein kinase CK2. âº CK2 phosphorylates ATF4 at serine 215. âº Phosphorylation of ATF4 by CK2 reduces the stability of ATF4. âº Inhibition of CK2 kinase activity results in an elevated transcription of ATF4. âº CK2 phosphorylation of ATF4 stimulates its transcription factor activity.

Keywords

Transcription Transcription factor Phosphorylation Protein stability Protein kinase

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Functional interaction of protein kinase CK2 and activating transcription factor 4 (ATF4), a key player in the cellular stress response

Authors

Emmanuel Ampofo, Tasja Sokolowsky, Claudia Götz, Mathias Montenarh,