Article ID Journal Published Year Pages File Type
10802653 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2013 9 Pages PDF
Abstract
► The cardiotonic steroid (CTS) ouabain induces in Sertoli cells a signaling cascade. ► This happens by its interaction with the α4 isoform of Na+,K+-ATPase. ► It induces phosphorylation of the activating transforming factor 1 (ATF-1). ► As a consequence, activated ATF-1 stimulates the expression of StAR protein. ► Interactions between endogenous CTS and α4 might be crucial for male fertility.
Keywords
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Cardiac glycoside ouabain induces activation of ATF-1 and StAR expression by interacting with the α4 isoform of the sodium pump in Sertoli cells
Authors
, , , , ,