Article ID Journal Published Year Pages File Type
10802654 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2013 9 Pages PDF
Abstract
► Low pH stabilizes the closed conformations of specific activating mutations of TRPV1 ► The S1 region plays an important role in TRPV1 channel gating ► TRPV1 and potassium channels might share a similar gating mechanism involving S1 ► The S1-pore interface stabilizes conformations associated with TRPV1 gating
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Protons stabilize the closed conformation of gain-of-function mutants of the TRPV1 channel
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