| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802657 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2013 | 11 Pages |
Abstract
⺠Proliferative and quiescent breast cancer micro-regions depend on mitochondrial ATP. ⺠Anti-mitochondrial therapy at nanomolar doses arrests breast tumor spheroid growth. ⺠Glycolysis and chemotherapy inhibitors do not affect breast tumor spheroid growth. ⺠Anti-mitochondrial therapy does not modify energy metabolism of normal breast spheroids. ⺠Anti-mitochondrial drugs prevent, and revert, breast tumor spheroid growth.
Keywords
autophagy-related gene 7Cytochrome oxidase subunit IVCOXIV2OGND1MCT-1PDHLC3BGLUTMCTsATG7PGC-1αPRLHIF-1αSDH2-oxoglutarate dehydrogenase2-oxoglutarateglucose transportersBreast cancer cellsuccinate dehydrogenaseOxidative phosphorylationLAMPlactate dehydrogenaseLDHhexokinasehypoxia inducible factor-1 alphapyruvate dehydrogenaseGlycolysis
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Authors
Edna Ayerim Mandujano-Tinoco, Juan Carlos Gallardo-Pérez, Alvaro MarÃn-Hernández, Rafael Moreno-Sánchez, Sara RodrÃguez-EnrÃquez,