Article ID Journal Published Year Pages File Type
10802671 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2013 14 Pages PDF
Abstract
► The C-terminus of TM4SF5 binds c-Src family kinases in preference to the inactive form. ► TM4SF5 requires a signaling link from c-Src to Tyr845 EGFR for invasive protrusion. ► Tailless TM4SF5 enhances c-Src/EGFR-dependent invasion even without EGF treatment. ► The C-terminus of TM4SF5 may play a negative regulatory role in hepatocyte invasion.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
The COOH-terminus of TM4SF5 in hepatoma cell lines regulates c-Src to form invasive protrusions via EGFR Tyr845 phosphorylation
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