| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802674 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2013 | 11 Pages |
Abstract
⺠FK506 modifies SOCE and TRPC1/type II IP3R coupling in platelets and MEG 01. ⺠Association between FKBP52/TRPC1 and FKBP52/Orai 1 is impaired by FK506 in platelets. ⺠FKBP52 silencing using siRNA reduces SOCE and coupling between TRPC1/type II IP3R. ⺠TRPC1 silencing reduces SOCE in MEG 01 thus reinforcing the role of TRPC1 in SOCE.
Keywords
PBSOrai1[Ca2 +]CSERCA2bCyPTRPCFKBPsRAPACypermethrinPPIaseFK506THRThapsigarginHBSFKBP52BSACYPsHEPES-buffered salinebovine serum albuminCSAImmunophilinTacrolimusThrombinRapamycinCAMcyclosporin ACyclophilinsrough endoplasmic reticulumcytosolic calcium concentrationPhosphate-buffered salineCalmodulinTransient receptor potential channelCalcineurinInositol 1,4,5-trisphosphate receptor
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Authors
Esther López, Alejandro Berna-Erro, Ginés M. Salido, Juan A. Rosado, Pedro C. Redondo,