| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802711 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2013 | 10 Pages |
Abstract
⺠Rhomboids are the most ancient family of intramembrane-cleaving proteases. ⺠The rhomboid domain of mammalian mitochondrial rhomboids is structurally similar to that of bacterial rhomboids. ⺠Whereas bacterial rhomboids use a dyad-based mechanism of catalysis, mitochondrial rhomboids might use a triad. ⺠Mitochondrial rhomboids regulate mitochondrial dynamics. ⺠Parl is emerging as a key regulator of mitochondrial quality control and seems implicated in Parkinson's disease.
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Authors
Danny V. Jeyaraju, Aditi Sood, Audrey Laforce-Lavoie, Luca Pellegrini,