| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802729 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 | 9 Pages |
Abstract
⺠Extensive secretion requires an adaption of acinar cell Ca2+-signaling machinery. ⺠We model two types of cell stimulation: short and prolonged presence of an agonist. ⺠Upon short stimulation mitochondria slightly regulate Ca2+ entry and ER refilling. ⺠Upon prolonged stimulation mitochondria ensure sustained Ca2+ entry and ER refilling. ⺠Mitochondria take up and release Ca2+ within Ca2+ microdomains.
Keywords
Mitochondrial Ca2+ concentrationCa2+ microdomainsMitochondrial Na+/Ca2+ exchangerInsP3[Ca2+]ERPMCATRPC1CGP37157FCCPNCXThapsigarginSOCEinositol 1,4,5-trisphosphate[Ca2+]cytAChAcetylcholineSOCendoplasmic reticulumPlasma membraneCytosolic Ca2+ concentrationSERCAMitochondriaElectron microscopyStore-operated calcium entryStore-operated Ca2+ entryStore-operated channel
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Authors
Olga Kopach, Ilya Kruglikov, Tatyana Pivneva, Nana Voitenko, Alexei Verkhratsky, Nataliya Fedirko,