| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802734 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 | 10 Pages |
Abstract
⺠c-Src-dependent activation of Ets1 was regulated by HDACs in bone-metastatic 1883 cells. ⺠c-Src/Ets1 pathway transactivated CXCR4 and caused nuclear-tyrosine phosphorylation only in 1833 clone. ⺠CXCR4-molecular changes due to c-Src had a functional role for metastasis chemoinvasion. ⺠c-Src expression, as occurs in response to microenvironmental stimuli, might influence migratory dissemination and gene expression profile. ⺠c-Src may be a predictive biomarker to define metastasis sensitivity patterns to HDAC inhibitors.
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Authors
Paola Bendinelli, Paola Maroni, Emanuela Matteucci, Maria Alfonsina Desiderio,