| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802738 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 | 10 Pages |
Abstract
⺠PKC α translocates into the nucleus as part of the NF-κB transcription complex. ⺠PKC α binds to pri-miRNA 15a, prevents its nuclear release and maturation to miRNA. ⺠Levels of PKC α and miRNA 15a are inversely related in different human cell lines. ⺠This signalling occurs via endothelin-1 binding to its surface receptors. ⺠miRNA 15a expression is dependent on expression of both endothelin receptors.
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Authors
Melanie von Brandenstein, Reinhard Depping, Ekaterine Schäfer, Hans-Peter Dienes, Jochen W.U. Fries,