| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802740 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 | 11 Pages |
Abstract
⺠NGAL knockdown evidently decreases MMPs expression and cell metastasis. ⺠C/EBP ζ overexpression significantly prevents cell metastasis. ⺠C/EBP ζ overexpression induces a strong decrease in NGAL and MMPs expression. ⺠C/EBP ζ directly represses the human NGAL gene promoter activity. ⺠NHE1 inhibition reduces cell metastasis via C/EBP ζ-mediated NGAL downregulation.
Keywords
MmpsPHIDdit3TSGPHEESCCNGALNHE12-mercaptoethanolNa+/H+ exchanger 1Extracellular pHIntracellular pHepithelial to mesenchymal transitioninterleukinEMTBreast cancerConditioned mediumneutrophil gelatinase-associated lipocalinMetastasisMatrix metalloproteinasesTumor suppressor geneOesophageal squamous cell carcinomaestrogen receptors
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Authors
Lihong Wang, Huawen Li, Jian Wang, Wei Gao, Yani Lin, Weina Jin, Guoqiang Chang, Ruojun Wang, Qinghua Li, Li Ma, Tianxiang Pang,