Induction of the intrinsic apoptosis pathway in insulin-secreting cells is dependent on oxidative damage of mitochondria but independent of caspase-12 activation

Article ID	Journal	Published Year	Pages	File Type
10802745	Biochimica et Biophysica Acta (BBA) - Molecular Cell Research	2011	9 Pages	PDF

Abstract

âº Caspase-9 is not a target of the ER-specific caspase-12 in insulin-producing cells. âº Activation of caspase-12 is not involved in cytokine-induced beta cell apoptosis. âº Cytokines induce beta cell death by ROS-mediated mitochondrial damage. âº Mitochondrially located catalase prevents ROS-induced damage of mitochondrial structures.

Keywords

second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI IAP IFN-γ Jnk TRAF-2 Mitochondrial apoptosis pathway 8-oxoG STAT-1 IL-1β T1DM iNOS 8-oxoguanine c-Jun N-terminal kinases MAPK NFκB ROS Hydrogen peroxide Oxidative damage Smac/DIABLO interferon-γ Interleukin-1β CHOP type 1 diabetes mellitus inducible nitric oxide synthase Cytokine TNF-α nuclear factor kappa B signal transducer and activator of transcription 1 Beta cell death inhibitor of apoptosis protein NAO Nitric oxide H2O2 mitogen-activated protein kinase Caspase-9 Reactive oxygen species