Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10802747 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 | 9 Pages |
Abstract
⺠Tau inhibits PrP-induced oligomerization of tubulin. ⺠Tau does not compete with PrP for binding site on tubulin. ⺠Tau stabilizes tubulin in a form less susceptible to PrP-induced oligomerization. ⺠Phosphorylation regulates Tau's ability to inhibit PrP-induced oligomerization. ⺠Tau phosphorylation may indirectly enhance neurotoxicity of cytosolic PrP.
Keywords
GPicellular form of prion proteinPMDSPrPscPrPcPrPGSK3pKaCBBEDCmAb1-ethyl-3-(3-dimethylaminopropyl)carbodiimideCoomassie Brilliant BlueMonoclonal antibodyAlzheimer diseaseProtein misfolding diseasesendoplasmic reticulumMapsmicrotubule-associated proteinsPrion proteinprotein kinase Aglycosylphosphatidylinositolglycogen synthase kinase 3
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Authors
Katarzyna M. Osiecka, Hanna Nieznanska, Krzysztof J. Skowronek, Jolanta Jozwiak, Krzysztof Nieznanski,