| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802750 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 | 9 Pages |
Abstract
⺠Skin dendritic cells (DC) constitutively express Neurotensin (NT) receptors 1 and 3. ⺠NT expression increases under inflammatory conditions in contrast to NTR1 and NTR3. ⺠NT downregulates LPS-induced signaling pathways NF-kB and JNK, while activating ERK. ⺠NT downregulates the expression of IL-6, TNF-α, IL-10 and VEGF, while activating EGF. ⺠NT downregulates the pro-inflammatory properties of DC and increases EGF expression.
Keywords
(DCS)(NT)(VEGF)(IL)(ECM)(LPS)(CNS)interferoninterleukinToll-like receptorDendritic cellsLangerhans cellscentral nervous systemepidermal growth factorVascular endothelial growth factorplatelet derived growth factortumor necrosis factorlipopolysaccharideExtracellular matrixneurotensinMelanocyte-stimulating hormonevasoactive intestinal peptidepituitary adenylate cyclase-activating peptidecalcitonin gene related peptideNeurotensin receptor
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Authors
LucÃlia da Silva, Bruno Miguel Neves, Liane Moura, Maria Teresa Cruz, Eugénia Carvalho,