Urban planning of the endoplasmic reticulum (ER): How diverse mechanisms segregate the many functions of the ER

Article ID	Journal	Published Year	Pages	File Type
10802755	Biochimica et Biophysica Acta (BBA) - Molecular Cell Research	2011	13 Pages	PDF

Abstract

âº This review summarizes mechanisms that lead to the targeting of ER proteins to individual membrane domains (e.g., rough ER). âº Formation of interactions between the Sec61 proteins, ribosomes and mRNAs is critical for rough ER targeting. âº The equilibrium between atlastins, reticulons and DP1/Yop1p determines the formation of smooth ER tubules. âº Targeting to the MAM depends on ER redox and on cytosolic or mitochondrial sorting motifs. âº Targeting to ERES, ERQC, and sites of peroxisome and lipid droplet biogenesis depend on COPI and COPII proteins.

Keywords

KDEL GRP EREs IP3R STIM1 SREBP TIP47 LRP6 ERMES RFP COP Russell bodies VAPB Endoplasmic reticulum exit sites Amfr BAP31 Lys-Asp-Glu-Leu low-density lipoprotein receptor-related protein 6 ERQC TRAP PDI ERAD GFP NADPH PAM ERK MAM SRP SNARE XBP1 BiP Ost Endoplasmic reticulum associated degradation TRAM CHOP Diacylglycerol acyltransferase signal recognition particle Endoplasmic reticulum (ER)sarco/endoplasmic reticulum Ca2+-ATPase endoplasmic reticulum mitochondria-associated membrane lipid droplet SERCA Stromal interaction molecule 1 X-box binding protein 1 Immunoglobulin binding protein glucose regulated protein protein disulfide isomerase green fluorescent protein red fluorescent protein PERK coat protein complex reduced nicotinamide adenine dinucleotide phosphate extracellular signal-regulated kinase Inositol 1,4,5-trisphosphate receptor Autocrine motility factor receptor