PLTP regulates STAT3 and NFÎºB in differentiated THP1 cells and human monocyte-derived macrophages

Article ID	Journal	Published Year	Pages	File Type
10802758	Biochimica et Biophysica Acta (BBA) - Molecular Cell Research	2011	8 Pages	PDF

Abstract

âº PLTP increases active STAT3 in human macrophages and differentiated THP1 cells. âº PLTP-mediated STAT3 activation does not depend on PLTP phospholipid transfer. âº PLTP-mediated increase in nuclear pSTAT3Tyr705 is inhibited by ABCA1 inhibition. âº PLTP reduces active NFÎºB p65 in human macrophages and differentiated THP1 cells. âº PLTP reduces inflammatory cytokines in macrophages and differentiated THP1 cells.

Keywords

TNFα Stat3 activation PLTP Mip1α IFNγ phorbol 12-myristate 13-acetate TLR JAK2 ABCA1 STAT3 LPS TBP TGFβ ATP-binding cassette transporter A1 PMA NFκB inflammation human monocyte-derived macrophage Interleukin 1 alpha tumor necrosis factor alpha Toll-like receptor tumor growth factor beta nuclear factor kappa-B Lipopolysaccharides signal transducer and activator of transcription 3 macrophage inflammatory protein 1 alpha Phospholipid transfer protein TATA binding protein Interferon gamma janus kinase-2