| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802762 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 | 11 Pages |
Abstract
⺠During apoptosis, Bax and Bak puncture the mitochondrial outer membrane. ⺠Bax and Bak activity is regulated by other members of the Bcl-2 family. ⺠Activation exposes the Bax and Bak BH3 domains to allow oligomerization. ⺠Bax and Bak oligomers form pores in the outer membrane via unknown mechanisms. ⺠Structures of oligomeric Bax or Bak may reveal novel drug targets.
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Authors
Dana Westphal, Grant Dewson, Peter E. Czabotar, Ruth M. Kluck,