| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802763 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 | 8 Pages |
Abstract
⺠This review highlights the various mechanisms that target Bcl-2 proteins to mitochondria. ⺠Multi-domain Bcl-2 proteins target to mitochondria via their C-terminal tail anchor. ⺠How membrane specificity is achieved for tail anchor containing Bcl-2 proteins is unclear, and may require interactions with other mitochondrial proteins. ⺠The mechanisms targeting BH3-only proteins to mitochondria are distinct from those used by the multi-domain proteins. ⺠Targeting of BH3 proteins involves both protein-lipid and protein-protein interactions on the OMM.
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Authors
Jennefer Lindsay, Mauro Degli Esposti, Andrew P. Gilmore,