| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802766 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 | 7 Pages |
Abstract
⺠After apoptosis induction, the initial lipid changes occurring in mitochondria appear to reflect an upstream deficiency in the biosynthesis of phospholipids including cardiolipin. ⺠Lysolipids are prominent among these initial changes and may facilitate the pro-apoptotic action of Bax and Bak that produces the piercing of mitochondria. ⺠Pro-apoptotic Bid provides a link between phospholipid deficiency and mitochondrial membranes by transporting lysolipids and binding to cardiolipin, affecting its re-modelling. ⺠Other changes in membrane lipids generally occur after the piercing of the outer mitochondrial membrane has occurred.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Massimo Crimi, Mauro Degli Esposti,