Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10802766 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 | 7 Pages |
Abstract
⺠After apoptosis induction, the initial lipid changes occurring in mitochondria appear to reflect an upstream deficiency in the biosynthesis of phospholipids including cardiolipin. ⺠Lysolipids are prominent among these initial changes and may facilitate the pro-apoptotic action of Bax and Bak that produces the piercing of mitochondria. ⺠Pro-apoptotic Bid provides a link between phospholipid deficiency and mitochondrial membranes by transporting lysolipids and binding to cardiolipin, affecting its re-modelling. ⺠Other changes in membrane lipids generally occur after the piercing of the outer mitochondrial membrane has occurred.
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Authors
Massimo Crimi, Mauro Degli Esposti,