| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802768 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 | 6 Pages |
Abstract
⺠We describe the role of mitochondria in caspase-8 signalling. ⺠Polyubiquitination of caspase-8 at the DISC modulates its activation. ⺠The cardiolipin enriched “mitosome” is a new activation platform for caspase-8. ⺠MTCH2/MIMP facilitates the recruitment of active tBid to the mitochondria. ⺠The type I/type II cell discrimination is also due to differences on XIAP levels.
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Authors
Chahrazade Kantari, Henning Walczak,