| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802777 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 | 7 Pages |
Abstract
⺠Molecular identity of the mPTP: still a work in progress. ⺠MOMP is primarily associated with MAC opening during apoptosis. ⺠Sustained MPT is mostly involved during necrosis. ⺠A crosstalk between MAC and mPTP links both necrotic and apoptotic processes during cell death.
Keywords
MPTMAC, mitochondrial apoptosis-induced channelVDAC, voltage-dependent anion-selective channelIMACSmPTP, mitochondrial permeability transition poremitochondrial outer membrane permeabilizationROSmitochondrial permeability transitionCSACyclosporine APharmacologyMOMPBcl-2 family proteinsPatch clampReactive oxygen species
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Authors
Kathleen W. Kinnally, Pablo M. Peixoto, Shin-Young Ryu, Laurent M. Dejean,