| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802778 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 | 11 Pages |
Abstract
⺠Upon mitochondrial membrane depolarisation, full-length PINK1 accumulates at the outer mitochondrial membrane and NIX translocates to the mitochondria. ⺠NIX and full-length PINK1 recruit parkin to the mitochondria, which leads to parkin-dependent ubiquitination of VDAC. ⺠Ubiquitination of VDAC recruits p62 while NIX recruits GABARAP to the mitochondria. ⺠NIX binds to LC3, which additionally binds p62. ⺠The combined effects of PINK1, parkin, NIX, VDAC, GABARAP, p62 and LC3 cause depolarised mitochondria to be removed via mitochondrial autophagy - mitophagy.
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Authors
Emma Deas, Nicholas W. Wood, Hélène Plun-Favreau,