Article ID Journal Published Year Pages File Type
10802781 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2011 10 Pages PDF
Abstract
►Growth stimuli and nutrient availability must be matched to avoid apoptotic stress. ►Oncogenic kinases can drive metabolism in growth factor deficiency. ►Bcl-2 family proteins respond to nutrient limitation to promote apoptosis. ►P53 plays a major role to mediate nutrient stress and induce Puma expression. ►Puma and Noxa promote while Mcl-1 suppresses apoptosis in nutrient deficiency.
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